PIWIL3

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, PIWIL3 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIWIL3-associated genes across cancer lineages are eIF4E, FoxM1, and INPP4B. Each is linked with PIWIL3 in more than 2 cancer types. Because this analysis shows association rather than direction, both PIWIL3-to-partner and partner-to-PIWIL3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIWIL3→partner) and Y-score (partner→PIWIL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECeIF4E →+0.170+3.472.020.00232
UCECFoxM1 →+0.177+2.070.048.00132
UCECINPP4B →-0.238-1.723.033.00732
UCECp38-MAPK_pT180_Y182 →-0.584-2.087<.001.00532
UCECp38-MAPK →-0.131-1.886.022.01532
UCECPCNA →+0.253+2.415<.001.00332
Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

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