Across TCGA cell cohorts, PIWIL3 mutation is significantly associated with the RNA expression of many other genes, with 533 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIWIL3-associated genes across cancer lineages are GML, OR11H2, and GOLGA6L6. Each is linked with PIWIL3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIWIL3-to-partner and partner-to-PIWIL3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIWIL3→partner) and Y-score (partner→PIWIL3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GML →	+0.107	+4.152	<.001	.009	3	2
OVARY	OR11H2 →	+0.046	+4.450	.002	.004	3	2
OESOPHAGUS	GOLGA6L6 →	+0.016	+4.906	<.001	.006	3	1
SOFT_TISSUE	OR13C7 →	+0.052	+5.369	<.001	.004	3	1
SKIN	ACP4 →	+0.020	+4.196	<.001	.002	3	1
SKIN	CPXCR1 →	+0.143	+3.707	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 533 associations by consensus.

Exploration

PIWIL3 survival (RNA) · tumor vs normal (RNA) · all PIWIL3 data types