Across TCGA patient cohorts, PIWIL2 mutation is significantly associated with the RNA expression of many other genes, with 4,922 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIWIL2-associated genes across cancer lineages are RN7SL478P, PHC2-AS1, and OR5M1. Each is linked with PIWIL2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PIWIL2-to-partner and partner-to-PIWIL2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIWIL2→partner) and Y-score (partner→PIWIL2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	RN7SL478P →	+0.369	+4.975	<.001	.002	3	3
SKCM	PHC2-AS1 →	+0.322	+1.813	.005	.002	3	3
PRAD	OR5M1 →	+0.052	+5.453	<.001	.002	3	3
SKCM	DUX4L18 →	+0.021	+3.486	<.001	<.001	3	3
COAD	RNU6-633P →	+0.792	+4.204	<.001	<.001	3	2
COAD	RNU6-862P →	+0.694	+3.602	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,922 associations by consensus.

Exploration

PIWIL2 survival (RNA) · tumor vs normal (RNA) · all PIWIL2 data types