DUX4L18

Q-omics provides the consensus-scored DUX4L18 profile across patient tissues and cancer cell-line models. DUX4L18 expression is associated with patient survival in 9 of 34 cancer types, with the highest sampling consensus in UCEC. Additionally, DUX4L18 RNA expression shows 4,381 significant pathway-activity associations, with the highest sampling consensus in STAD. Together, these results highlight UCEC, and STAD as cancer lineages where DUX4L18 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.

Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.

Survival associations

This table summarizes DUX4L18 survival associations across molecular data types. DUX4L18 RNA expression shows survival associations in the most cancer types (9). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.

DUX4L18 data type	Survival analysis	Lineage consensus	Lineage of highest sampling consensus
RNA	Kaplan–Meier	9	UCEC (72)	view →

This table ranks reproducible DUX4L18 RNA expression–survival associations across cancer types. High DUX4L18 expression shows unfavorable associations in UCEC, ESCA, PCPG, LUAD, HNSC and SARC. The UCEC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .002). Together, the overview and detailed table identify UCEC as the clearest survival context for DUX4L18 RNA expression.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	OS	Tertile	II,III,IV	0.198	0.768	.002	72	view →
ESCA	OS	Tertile	All	0.276	0.711	<.001	54	view →
PCPG	OS	Tertile	All	0.032	0.983	<.001	36	view →
LUAD	OS	Tertile	III,IV	0.239	0.687	.002	36	view →
HNSC	DFS	Tertile	All	0.432	0.634	.020	18	view →
SARC	DFS	Tertile	All	0.095	0.632	.002	18	view →

Pink = unfavorable, green = favorable. all 9 lineages →

DUX4L18-UCEC (OS)

Explore this curve interactively →