PITX3

Across TCGA patient cohorts, PITX3 protein abundance is significantly associated with the protein abundance of many other proteins, with 383 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PITX3-associated proteins across cancer lineages are SLC25A23, SYN1_S553, and SYN2_S542. Each is linked with PITX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PITX3-to-partner and partner-to-PITX3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PITX3 versus SLC25A23 in GBM, with a Pearson correlation of 0.56.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PITX3→partner) and Y-score (partner→PITX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SLC25A23 →	+0.681	+0.972	<.001	<.001	3	1
GBM	SYN1_S553 →	+0.947	+1.074	<.001	<.001	3	1
GBM	SYN2_S542 →	+2.026	+0.943	<.001	.001	3	1
GBM	SYNRG_S919 →	-0.851	-1.126	<.001	<.001	3	1
GBM	TLN2 →	+0.528	+1.121	.002	<.001	3	1
GBM	UQCRFS1 →	+0.510	+1.109	.006	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 383 associations by consensus.

PITX3 vs SLC25A23 — GBM

Explore this scatter interactively →