PITX3

Across TCGA pan-cancer cohorts, PITX3 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of PITX3’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where PITX3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PITX3 is over-expressed in tumor, although a few such as KICH and KIRC show the opposite, repressed pattern.

THCA, COAD, and KICH are the cancer types where PITX3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PITX3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	All	+0.695	<.001	9	view →
COAD	All	II,III,IV	+0.081	<.001	8	view →
KICH	All	All	−0.478	<.001	7	view →
KIRC	Male	II,III,IV	−0.251	<.001	7	view →
UCEC	All	IV	+0.540	.001	6	view →
LUSC	All	II,III,IV	+0.418	<.001	6	view →
LIHC	All	All	+0.024	<.001	5	view →
LUAD	All	IV	+0.265	.008	2	view →
KIRP	All	All	−0.162	.045	1	view →
CHOL	All	All	+0.121	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

PITX3–THCA

Open the THCA breakdown →