PITX3

Across TCGA pan-cancer cohorts, PITX3 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated PITX3 data layer compared with 2 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher PITX3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PITX3 expression acts as an unfavorable survival marker, although some lineages such as LUSC and SKCM show a favorable association.

ACC, LUAD, and LUSC are the cancer types where PITX3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	OS	Median	II,III,IV	0.373	0.789	<.001	119	view →
LUAD	OS	Median	All	0.261	0.443	<.001	112	view →
LUSC	OS	Median	II,III,IV	0.508	0.290	.001	64	view →
MESO	OS	Tertile	All	0.404	0.658	.002	56	view →
BLCA	DFS	Median	II,III,IV	0.447	0.567	.001	54	view →
LIHC	OS	Median	III,IV	0.288	0.657	.001	54	view →
UVM	DFS	Quartile	III,IV	0.375	0.798	.006	52	view →
UCEC	DFS	Median	All	0.786	0.884	<.001	44	view →
KIRC	OS	Tertile	All	0.735	0.837	.002	39	view →
THYM	OS	Tertile	All	0.912	1.000	.001	26	view →
SKCM	DFS	Median	IV	0.744	0.145	<.001	20	view →
UCS	DFS	Quartile	II,III,IV	0.692	0.154	.002	18	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

PITX3–ACC (OS)

Open the ACC breakdown →