PITX3

Across TCGA patient cohorts, PITX3 mutation is significantly associated with the RNA expression of many other genes, with 81 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PITX3-associated genes across cancer lineages are RNU4-13P, MIR4510, and MIR4766. Each is linked with PITX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PITX3-to-partner and partner-to-PITX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-13P grouped by PITX3-low versus PITX3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PITX3→partner) and Y-score (partner→PITX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU4-13P →	+0.168	+4.242	<.001	.006	3	2
UCEC	MIR4510 →	+0.342	+4.453	<.001	<.001	3	1
UCEC	MIR4766 →	+0.645	+2.839	.001	.004	3	1
UCEC	ATP5MGP6 →	+0.396	+3.097	<.001	.004	3	1
UCEC	VN1R91P →	+0.295	+3.621	<.001	.003	3	1
UCEC	IGHV1OR15-1 →	+0.180	+3.479	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 81 associations by consensus.

RNU4-13P by PITX3 expression — UCEC

Explore this box plot interactively →