PITX3

Across TCGA patient cohorts, PITX3 mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PITX3-associated genes across cancer lineages are CD8+ T-cells, CD8+ Tcm, and CD8+ Tem. Each is linked with PITX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PITX3-to-partner and partner-to-PITX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ T-cells grouped by PITX3-low versus PITX3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PITX3→partner) and Y-score (partner→PITX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CD8+ T-cells →	+0.027	+2.845	<.001	.016	3	1
UCEC	CD8+ Tcm →	+0.029	+2.935	.008	.013	3	1
UCEC	CD8+ Tem →	+0.004	+5.066	<.001	.033	3	1
UCEC	B-cells →	+0.036	+1.895	.019	.048	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

CD8+ T-cells by PITX3 expression — UCEC

Explore this box plot interactively →