PITX3

Across TCGA cell cohorts, PITX3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,546 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PITX3-associated GO terms across cancer lineages are Heterochromatin organization, Protein localization to nuclear inner membrane, and Heterochromatin formation. Each is linked with PITX3 in more than 7 cancer types. Because this analysis shows association rather than direction, both PITX3-to-partner and partner-to-PITX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Heterochromatin organization grouped by PITX3-low versus PITX3-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PITX3→partner) and Y-score (partner→PITX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Heterochromatin organization →	+0.057	+2.049	.001	.001	2	8
SOFT_TISSUE	Protein localization to nuclear inner membrane →	+0.115	+2.176	<.001	<.001	3	7
SOFT_TISSUE	Heterochromatin formation →	+0.059	+2.032	.001	<.001	3	7
SOFT_TISSUE	Response to dietary excess →	-0.151	-2.323	<.001	<.001	3	6
SOFT_TISSUE	Immune response-regulating cell surface receptor signaling pathway →	-0.056	-1.916	.003	.001	3	6
SOFT_TISSUE	Cell cycle phase transition →	+0.079	+1.503	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,546 associations by consensus.

Heterochromatin organization by PITX3 expression — SOFT_TISSUE

Explore this box plot interactively →