PITX3

Across TCGA cell cohorts, PITX3 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PITX3-associated genes across cancer lineages are TCF15, KRTAP4-4, and SLC15A5. Each is linked with PITX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PITX3-to-partner and partner-to-PITX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TCF15 grouped by PITX3-low versus PITX3-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PITX3→partner) and Y-score (partner→PITX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TCF15 →	+0.454	+4.350	.001	.005	3	1
BLOOD_Lymphoma	KRTAP4-4 →	+0.024	+4.643	<.001	.005	3	1
LARGE_INTESTINE	SLC15A5 →	+0.017	+4.415	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

TCF15 by PITX3 expression — BLOOD_Lymphoma

Explore this box plot interactively →