PIPSL

Across TCGA patient cohorts, PIPSL mutation is significantly associated with the RNA expression of many other genes, with 2,060 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIPSL-associated genes across cancer lineages are RN7SL422P, CIDECP1, and RTP4. Each is linked with PIPSL in more than 3 cancer types. Because this analysis shows association rather than direction, both PIPSL-to-partner and partner-to-PIPSL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL422P grouped by PIPSL-low versus PIPSL-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIPSL→partner) and Y-score (partner→PIPSL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RN7SL422P →	+0.089	+4.424	<.001	.008	3	4
SKCM	CIDECP1 →	+0.402	+2.945	<.001	<.001	3	3
UCEC	RTP4 →	-0.983	-1.989	<.001	.001	3	3
HNSC	RN7SKP294 →	+0.099	+4.754	<.001	.005	3	2
HNSC	RNU6-818P →	+0.262	+4.636	<.001	.006	3	2
BRCA	MIR583 →	+1.713	+6.064	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,060 associations by consensus.

RN7SL422P by PIPSL expression — HNSC

Explore this box plot interactively →