PIPSL

Across TCGA pan-cancer cohorts, PIPSL RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of PIPSL’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where PIPSL RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PIPSL is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

LIHC, HNSC, and COAD are the cancer types where PIPSL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PIPSL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Male	All	+0.302	<.001	9	view →
HNSC	Male	II,III,IV	+0.262	<.001	8	view →
COAD	All	II,III,IV	+0.382	<.001	6	view →
BRCA	All	II,III,IV	+0.199	<.001	4	view →
STAD	All	All	+0.179	.006	4	view →
KICH	Male	All	−0.312	<.001	3	view →
CHOL	All	All	+0.578	.002	2	view →
LUAD	All	IV	+0.550	.008	2	view →
UCEC	All	III,IV	+0.473	.035	2	view →
THCA	All	IV	−0.287	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

PIPSL–LIHC

Open the LIHC breakdown →