PINX1

Across TCGA patient cohorts, PINX1 mutation is significantly associated with the RNA expression of many other genes, with 71 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible PINX1-associated genes across cancer lineages are CSPG4P3Y, SNORD115-22, and PABPC1L2B-AS1. Each is linked with PINX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PINX1-to-partner and partner-to-PINX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CSPG4P3Y grouped by PINX1-low versus PINX1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PINX1→partner) and Y-score (partner→PINX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	CSPG4P3Y →	+0.014	+7.640	<.001	.009	3	2
SKCM	SNORD115-22 →	+0.383	+7.816	<.001	.008	3	2
SKCM	PABPC1L2B-AS1 →	+0.034	+7.816	<.001	.008	3	2
LUAD	MIR3691 →	+0.603	+3.926	<.001	.005	3	2
COAD	TRAJ6 →	+0.945	+3.897	.005	.007	3	2
BRCA	RNA5SP26 →	+0.378	+8.055	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 71 associations by consensus.

CSPG4P3Y by PINX1 expression — BLCA

Explore this box plot interactively →