PINX1

Across TCGA pan-cancer cohorts, PINX1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PINX1’s most consistent transcriptional readouts.

The strongest signal is observed in stomach adenocarcinoma (STAD), where PINX1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PINX1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

STAD, THCA, and LIHC are the cancer types where PINX1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PINX1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
STAD	All	II,III,IV	+0.989	<.001	9	view →
THCA	Female	All	−0.332	<.001	8	view →
LIHC	Male	II,III,IV	+0.867	<.001	7	view →
UCEC	All	III,IV	+0.856	.003	6	view →
COAD	All	II,III,IV	+0.578	<.001	6	view →
CHOL	Male	All	+1.206	<.001	5	view →
KICH	Female	All	−0.569	<.001	5	view →
READ	All	III,IV	+1.735	.011	4	view →
LUSC	Male	All	+0.352	<.001	4	view →
BRCA	Female	II,III,IV	−0.313	<.001	4	view →
LUAD	Male	II,III,IV	+0.340	.043	3	view →
ESCA	All	All	+0.627	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PINX1–STAD

Open the STAD breakdown →