PINX1

Across TCGA cell cohorts, PINX1 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PINX1-associated genes across cancer lineages are CARTPT, C10orf71, and PRR20B. Each is linked with PINX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both PINX1-to-partner and partner-to-PINX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CARTPT grouped by PINX1-low versus PINX1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PINX1→partner) and Y-score (partner→PINX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	CARTPT →	+0.023	+6.266	<.001	<.001	3	1
LUNG_NSCLC_LUAD	C10orf71 →	+0.029	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	PRR20B →	+0.036	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	PRR20A →	+0.036	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	PRR20D →	+0.036	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	PRR20E →	+0.036	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

CARTPT by PINX1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →