PINK1-AS

Across TCGA pan-cancer cohorts, PINK1-AS RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated PINK1-AS data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher PINK1-AS RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PINK1-AS expression acts as an unfavorable survival marker, although some lineages such as KIRC and COAD show a favorable association.

BLCA, KICH, and KIRC are the cancer types where PINK1-AS RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Tertile	All	0.260	0.614	<.001	84	view →
KICH	DFS	Median	III,IV	0.373	1.000	.008	59	view →
KIRC	OS	Median	All	0.715	0.540	<.001	53	view →
LGG	DFS	Median	All	0.634	0.845	<.001	53	view →
ACC	DFS	Tertile	All	0.228	0.826	<.001	47	view →
COAD	OS	Tertile	II,III,IV	0.890	0.685	.002	46	view →
UCEC	OS	Tertile	All	0.728	0.530	.007	42	view →
LIHC	OS	Quartile	All	0.656	0.820	.005	26	view →
SKCM	DFS	Median	III,IV	0.169	0.481	.002	25	view →
THYM	DFS	Median	II,III,IV	0.938	0.754	.006	17	view →
PAAD	DFS	Tertile	All	0.615	0.372	.011	15	view →
SARC	OS	Tertile	All	0.624	0.821	<.001	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

PINK1-AS–BLCA (DFS)

Open the BLCA breakdown →