PINK1-AS

Across TCGA pan-cancer cohorts, PINK1-AS RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PINK1-AS’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PINK1-AS RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PINK1-AS is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

KIRC, THCA, and HNSC are the cancer types where PINK1-AS tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PINK1-AS RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.550	<.001	12	view →
THCA	Male	III,IV	−1.180	<.001	9	view →
HNSC	All	All	+0.294	.005	6	view →
KICH	All	All	−0.444	<.001	5	view →
STAD	All	II,III,IV	+0.677	<.001	4	view →
LIHC	Female	All	+0.262	.013	4	view →
BRCA	Female	All	−0.170	.019	4	view →
CHOL	All	All	+0.789	<.001	3	view →
BLCA	Male	All	+0.521	.017	3	view →
UCEC	All	IV	−1.810	.045	2	view →
PRAD	All	All	+0.297	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

PINK1-AS–KIRC

Open the KIRC breakdown →