PIKFYVE

Across TCGA cell cohorts, PIKFYVE mutation is significantly associated with the RNA expression of many other genes, with 524 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIKFYVE-associated genes across cancer lineages are OR2AJ1, ATG4C, and CCNB3. Each is linked with PIKFYVE in more than 2 cancer types. Because this analysis shows association rather than direction, both PIKFYVE-to-partner and partner-to-PIKFYVE results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR2AJ1 grouped by PIKFYVE-low versus PIKFYVE-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIKFYVE→partner) and Y-score (partner→PIKFYVE) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	OR2AJ1 →	+0.019	+3.452	<.001	.004	3	3
LARGE_INTESTINE	ATG4C →	+0.553	+2.364	<.001	<.001	3	2
LARGE_INTESTINE	CCNB3 →	+0.437	+2.389	.006	.006	3	2
LARGE_INTESTINE	GLMN →	+0.532	+3.043	.001	<.001	3	2
LUNG_NSCLC_LUAD	CFAP47 →	+0.462	+3.584	<.001	.004	3	2
LUNG_NSCLC_LUAD	LRRC3C →	+0.076	+2.935	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 524 associations by consensus.

OR2AJ1 by PIKFYVE expression — BLOOD_Lymphoma

Explore this box plot interactively →