PIKFYVE

Across TCGA pan-cancer cohorts, PIKFYVE RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of PIKFYVE’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PIKFYVE RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PIKFYVE is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

HNSC, THCA, and LIHC are the cancer types where PIKFYVE tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PIKFYVE RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.625	.001	9	view →
THCA	All	All	−0.541	<.001	8	view →
LIHC	All	All	+0.451	<.001	7	view →
BRCA	Female	All	−0.370	<.001	6	view →
KICH	All	All	−0.657	<.001	5	view →
STAD	All	II,III,IV	+0.663	.003	3	view →
CHOL	All	All	+1.217	<.001	2	view →
PRAD	All	All	+0.354	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

PIKFYVE–HNSC

Open the HNSC breakdown →