PIK3R3

Across TCGA patient cohorts, PIK3R3 protein abundance is significantly associated with the RNA expression of many other genes, with 352 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible PIK3R3-associated genes across cancer lineages are MIR542, PLS3, and CORO2B. Each is linked with PIK3R3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIK3R3-to-partner and partner-to-PIK3R3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PIK3R3 versus MIR542 in CCRCC, with a Pearson correlation of 0.78.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3R3→partner) and Y-score (partner→PIK3R3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	MIR542 →	+1.460	+0.697	<.001	.003	3	2
CCRCC	PLS3 →	-0.745	-0.623	.008	.008	3	1
CCRCC	CORO2B →	-0.874	-0.495	.005	.005	3	1
CCRCC	MTMR9 →	-0.422	-0.473	.003	.009	3	1
CCRCC	DMPK →	-1.014	-0.658	.007	.006	3	1
CCRCC	PIP5K1B →	-0.713	-0.485	.006	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 352 associations by consensus.

PIK3R3 vs MIR542 — CCRCC

Explore this scatter interactively →