PIK3R3

Across TCGA pan-cancer cohorts, PIK3R3 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PIK3R3’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where PIK3R3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PIK3R3 is over-expressed in tumor, although a few such as LUAD and KIRP show the opposite, repressed pattern.

LIHC, LUAD, and KIRP are the cancer types where PIK3R3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PIK3R3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+1.355	<.001	9	view →
LUAD	All	III,IV	−1.189	<.001	8	view →
KIRP	Male	All	−0.841	<.001	8	view →
BRCA	All	All	+0.716	<.001	8	view →
UCEC	All	III,IV	+2.356	<.001	6	view →
LUSC	Male	II,III,IV	−1.306	<.001	6	view →
THCA	Male	III,IV	−1.128	.004	6	view →
KIRC	Female	All	+0.957	<.001	6	view →
KICH	All	All	−0.657	.008	5	view →
STAD	All	II,III,IV	+0.745	.008	4	view →
CHOL	All	All	+1.123	<.001	3	view →
PRAD	All	All	+0.336	.009	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PIK3R3–LIHC

Open the LIHC breakdown →