PIK3R2

Across TCGA patient cohorts, PIK3R2 mutation is significantly associated with the RNA expression of many other genes, with 1,726 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIK3R2-associated genes across cancer lineages are BNIP3, MSMO1, and RNA5SP485. Each is linked with PIK3R2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIK3R2-to-partner and partner-to-PIK3R2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BNIP3 grouped by PIK3R2-low versus PIK3R2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3R2→partner) and Y-score (partner→PIK3R2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	BNIP3 →	+0.787	+3.191	<.001	<.001	3	2
UCEC	MSMO1 →	+0.506	+2.222	.001	<.001	3	2
CESC	RNA5SP485 →	+0.292	+4.384	<.001	.008	3	2
HNSC	RNU1-6P →	+0.325	+4.578	<.001	.008	3	2
LUSC	LINC02301 →	+0.615	+3.505	.007	.007	3	2
LUSC	MIR8076 →	+0.249	+3.247	.004	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,726 associations by consensus.

BNIP3 by PIK3R2 expression — UCEC

Explore this box plot interactively →