PIK3R2

Across TCGA pan-cancer cohorts, PIK3R2 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated PIK3R2 data layer compared with 5 for mutation status.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher PIK3R2 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PIK3R2 expression acts as an unfavorable survival marker, although some lineages such as CESC and LUSC show a favorable association.

LIHC, CESC, and SKCM are the cancer types where PIK3R2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Quartile	All	0.559	0.792	<.001	82	view →
CESC	DFS	Median	All	0.683	0.401	<.001	74	view →
SKCM	OS	Median	All	0.827	0.913	<.001	69	view →
KIRC	DFS	Tertile	All	0.546	0.688	.003	64	view →
ACC	DFS	Tertile	II,III,IV	0.493	0.876	.012	43	view →
LUSC	OS	Median	All	0.732	0.617	.002	42	view →
CHOL	DFS	Quartile	II,III,IV	0.753	0.249	.004	36	view →
LUAD	DFS	Quartile	IV	0.430	0.912	.003	30	view →
READ	DFS	Median	III,IV	0.555	0.205	.004	30	view →
HNSC	OS	Quartile	III,IV	0.554	0.205	.009	23	view →
SARC	OS	Tertile	All	0.657	0.859	<.001	20	view →
COAD	OS	Median	IV	0.277	0.760	.016	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

PIK3R2–LIHC (OS)

Open the LIHC breakdown →