PIK3CD

Across TCGA cell cohorts, PIK3CD mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PIK3CD-associated genes across cancer lineages are KHDC3L, OR6N1, and TPD52L3. Each is linked with PIK3CD in more than 1 cancer types. Because this analysis shows association rather than direction, both PIK3CD-to-partner and partner-to-PIK3CD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KHDC3L grouped by PIK3CD-low versus PIK3CD-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3CD→partner) and Y-score (partner→PIK3CD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	KHDC3L →	+0.174	+3.096	<.001	.005	3	2
URINARY_TRACT	OR6N1 →	+0.013	+5.087	<.001	.004	3	1
SKIN	TPD52L3 →	+0.005	+5.022	<.001	.002	3	1
SKIN	MBD3L5 →	+0.021	+4.415	<.001	.007	3	1
BLOOD_Leukemia	GML →	+0.073	+2.982	<.001	.007	3	1
BLOOD_Leukemia	HAPLN1 →	+0.109	+3.657	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

KHDC3L by PIK3CD expression — BLOOD_Leukemia

Explore this box plot interactively →