PIK3CD

Across TCGA pan-cancer cohorts, PIK3CD RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PIK3CD’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PIK3CD RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PIK3CD is over-expressed in tumor, although a few such as COAD and UCEC show the opposite, repressed pattern.

HNSC, KIRC, and COAD are the cancer types where PIK3CD tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PIK3CD RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.487	<.001	12	view →
KIRC	Female	All	+1.043	<.001	11	view →
COAD	Female	II,III,IV	−0.805	<.001	8	view →
UCEC	All	All	−1.446	<.001	6	view →
BRCA	Female	II,III,IV	−0.438	<.001	6	view →
KICH	All	All	−0.927	<.001	5	view →
STAD	All	II,III,IV	+0.767	.017	2	view →
KIRP	All	All	+0.513	.009	2	view →
PRAD	All	All	−0.361	.013	2	view →
CHOL	All	All	+1.260	.003	1	view →
BLCA	All	IV	−0.770	.017	1	view →
LIHC	Male	All	−0.524	.009	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PIK3CD–HNSC

Open the HNSC breakdown →