PIK3C2G

Across TCGA patient cohorts, PIK3C2G mutation is significantly associated with the RNA expression of many other genes, with 4,570 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIK3C2G-associated genes across cancer lineages are RPA2, TAF9, and SHLD3. Each is linked with PIK3C2G in more than 3 cancer types. Because this analysis shows association rather than direction, both PIK3C2G-to-partner and partner-to-PIK3C2G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPA2 grouped by PIK3C2G-low versus PIK3C2G-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3C2G→partner) and Y-score (partner→PIK3C2G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RPA2 →	+0.307	+1.398	.005	.004	3	4
UCEC	TAF9 →	+0.628	+2.000	<.001	<.001	3	4
SKCM	SHLD3 →	+0.254	+1.156	.009	.004	3	3
HNSC	MRPL48P1 →	+0.300	+2.833	<.001	.007	3	3
ESCA	RNA5SP413 →	+0.309	+5.247	<.001	.006	3	3
UCEC	RBBP8 →	+0.601	+1.338	<.001	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,570 associations by consensus.

RPA2 by PIK3C2G expression — UCEC

Explore this box plot interactively →