PIK3C2G

Across TCGA pan-cancer cohorts, PIK3C2G RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated PIK3C2G data layer compared with 11 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher PIK3C2G RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PIK3C2G expression acts as an unfavorable survival marker, although some lineages such as LGG and OV show a favorable association.

SKCM, THCA, and LGG are the cancer types where PIK3C2G RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Quartile	All	0.233	0.379	<.001	46	view →
THCA	DFS	Tertile	II,III,IV	0.534	0.825	.001	45	view →
LGG	OS	Median	All	0.885	0.734	<.001	41	view →
LUAD	OS	Median	III,IV	0.380	0.593	.005	39	view →
KIRP	DFS	Median	II,III,IV	0.240	0.717	.003	35	view →
OV	OS	Median	All	0.372	0.289	.004	34	view →
ACC	OS	Median	III,IV	0.195	0.742	.007	33	view →
PAAD	OS	Quartile	All	0.222	0.814	<.001	33	view →
THYM	OS	Tertile	II,III,IV	0.868	1.000	.006	24	view →
LIHC	OS	Median	All	0.839	0.721	.015	22	view →
UVM	OS	Tertile	All	0.292	0.674	.035	18	view →
SCLC	DFS	Quartile	II,III,IV	0.556	0.214	.012	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

PIK3C2G–SKCM (OS)

Open the SKCM breakdown →