PIK3C2G

Across TCGA pan-cancer cohorts, PIK3C2G RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PIK3C2G’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PIK3C2G RNA is repressed in tumor relative to normal tissue. In most cancer types PIK3C2G is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, KIRP, and COAD are the cancer types where PIK3C2G tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PIK3C2G RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	−3.125	<.001	12	view →
KIRP	Male	All	−3.070	<.001	11	view →
COAD	All	IV	−0.184	<.001	11	view →
THCA	Female	II,III,IV	−0.177	<.001	9	view →
KICH	All	III,IV	−2.254	.001	8	view →
LIHC	Male	III,IV	−1.492	<.001	8	view →
BRCA	Female	All	−2.411	<.001	6	view →
HNSC	Male	II,III,IV	−0.786	<.001	6	view →
CHOL	Female	All	−2.816	<.001	5	view →
STAD	All	All	−0.991	.006	5	view →
READ	All	All	−0.216	<.001	5	view →
PAAD	All	All	+1.957	.012	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PIK3C2G–KIRC

Open the KIRC breakdown →