PIK3C2G

Across TCGA patient cohorts, PIK3C2G mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIK3C2G-associated genes across cancer lineages are 4E-BP1_pT70, p21, and p38-MAPK_pT180_Y182. Each is linked with PIK3C2G in more than 2 cancer types. Because this analysis shows association rather than direction, both PIK3C2G-to-partner and partner-to-PIK3C2G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1_pT70 grouped by PIK3C2G-low versus PIK3C2G-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3C2G→partner) and Y-score (partner→PIK3C2G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1_pT70 →	+0.080	+1.807	.019	.024	3	3
SKCM	p21 →	-0.262	-1.584	.020	.007	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.357	-1.321	.007	.027	3	2
UCEC	p90 RSK →	+0.131	+1.512	.022	.017	3	2
UCEC	PCNA →	+0.284	+1.807	<.001	<.001	3	2
UCEC	Shc_pY317 →	-0.145	-1.807	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

4E-BP1_pT70 by PIK3C2G expression — UCEC

Explore this box plot interactively →