PIK3C2G

Across TCGA cell cohorts, PIK3C2G mutation is significantly associated with the RNA expression of many other genes, with 255 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIK3C2G-associated genes across cancer lineages are LCE3D, FAM86B2, and XAGE5. Each is linked with PIK3C2G in more than 1 cancer types. Because this analysis shows association rather than direction, both PIK3C2G-to-partner and partner-to-PIK3C2G results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCE3D grouped by PIK3C2G-low versus PIK3C2G-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3C2G→partner) and Y-score (partner→PIK3C2G) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	LCE3D →	+0.124	+2.643	.001	.005	3	2
SKIN	FAM86B2 →	+0.783	+2.936	<.001	<.001	3	2
SKIN	XAGE5 →	+0.411	+1.691	.007	.009	3	2
SKIN	FAM86B1 →	+0.747	+2.158	.004	.004	3	2
LARGE_INTESTINE	ORC4 →	+0.607	+3.321	.001	.003	3	2
LARGE_INTESTINE	TSFM →	+0.453	+3.192	.002	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 255 associations by consensus.

LCE3D by PIK3C2G expression — BLOOD_Lymphoma

Explore this box plot interactively →