PIK3AP1

Across TCGA patient cohorts, PIK3AP1 mutation is significantly associated with the RNA expression of many other genes, with 5,993 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIK3AP1-associated genes across cancer lineages are PSMD9, CENPO, and SEC13. Each is linked with PIK3AP1 in more than 3 cancer types. Because this analysis shows association rather than direction, both PIK3AP1-to-partner and partner-to-PIK3AP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PSMD9 grouped by PIK3AP1-low versus PIK3AP1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIK3AP1→partner) and Y-score (partner→PIK3AP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PSMD9 →	+0.321	+2.153	<.001	<.001	3	4
UCEC	CENPO →	+0.399	+1.695	.001	.006	3	4
UCEC	SEC13 →	+0.370	+2.839	<.001	<.001	3	4
UCEC	UFD1 →	+0.365	+1.928	<.001	<.001	3	4
COAD	RCC1 →	+0.432	+3.362	.008	.004	3	4
UCEC	GINS3 →	+0.456	+1.699	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,993 associations by consensus.

PSMD9 by PIK3AP1 expression — UCEC

Explore this box plot interactively →