PIK3AP1

Across TCGA pan-cancer cohorts, PIK3AP1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated PIK3AP1 data layer compared with 6 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC), where higher PIK3AP1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated PIK3AP1 expression acts as an unfavorable survival marker, although some lineages such as CESC and SKCM show a favorable association.

CESC, SKCM, and UVM are the cancer types where PIK3AP1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CESC	DFS	Quartile	II,III,IV	0.858	0.515	.001	94	view →
SKCM	OS	Median	All	0.410	0.260	<.001	54	view →
UVM	OS	Tertile	All	0.410	0.853	.004	40	view →
KIRP	OS	Quartile	II,III,IV	0.809	0.331	.004	34	view →
LGG	OS	Quartile	All	0.354	0.509	.002	28	view →
HNSC	DFS	Median	III,IV	0.353	0.233	.003	27	view →
SCLC	DFS	Median	All	0.758	0.478	<.001	21	view →
KICH	DFS	Quartile	II,III,IV	0.504	1.000	.004	18	view →
ACC	OS	Quartile	III,IV	0.212	1.000	.002	16	view →
LUAD	DFS	Tertile	IV	0.789	0.157	.020	16	view →
THYM	OS	Quartile	All	0.706	1.000	.012	15	view →
CHOL	DFS	Median	III,IV	0.127	0.647	.006	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

PIK3AP1–CESC (DFS)

Open the CESC breakdown →