PIGU

Across TCGA patient cohorts, PIGU mutation is significantly associated with the RNA expression of many other genes, with 1,179 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIGU-associated genes across cancer lineages are RNA5SP198, MIR3129, and AACS. Each is linked with PIGU in more than 1 cancer types. Because this analysis shows association rather than direction, both PIGU-to-partner and partner-to-PIGU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP198 grouped by PIGU-low versus PIGU-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGU→partner) and Y-score (partner→PIGU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNA5SP198 →	+0.277	+5.144	<.001	.003	3	2
CESC	MIR3129 →	+0.752	+4.760	<.001	.003	3	2
UCEC	AACS →	+0.451	+2.436	.005	.002	3	2
UCEC	ALKBH5 →	+0.461	+3.087	.002	<.001	3	2
UCEC	ANKRD52 →	+0.617	+2.609	<.001	.006	3	2
UCEC	VPS53 →	+0.424	+3.807	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,179 associations by consensus.

RNA5SP198 by PIGU expression — CESC

Explore this box plot interactively →