PIGU

Across TCGA pan-cancer cohorts, PIGU RNA differs between tumor and matched normal tissue in 18 of 18 cancer types tested, making tumor–normal expression one of PIGU’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where PIGU RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PIGU is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

BLCA, COAD, and LUAD are the cancer types where PIGU tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PIGU RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	III,IV	+1.061	<.001	11	view →
COAD	Male	II,III,IV	+0.938	<.001	11	view →
LUAD	All	III,IV	+0.863	<.001	11	view →
LIHC	Female	II,III,IV	+1.995	<.001	9	view →
STAD	Male	II,III,IV	+1.302	<.001	9	view →
HNSC	Male	III,IV	+0.985	<.001	9	view →
LUSC	Male	II,III,IV	+1.102	<.001	8	view →
KIRP	All	II,III,IV	+0.733	<.001	7	view →
BRCA	All	III,IV	+1.161	<.001	6	view →
CHOL	Male	All	+2.501	<.001	5	view →
KICH	Female	All	−0.702	<.001	4	view →
PAAD	Male	All	+0.645	.009	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 18 lineages.

PIGU–BLCA

Open the BLCA breakdown →