PIGU

Across TCGA pan-cancer cohorts, PIGU RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated PIGU data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher PIGU RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PIGU expression acts as an unfavorable survival marker, although some lineages such as READ and THYM show a favorable association.

LIHC, BLCA, and UVM are the cancer types where PIGU RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Median	All	0.595	0.774	<.001	104	view →
BLCA	OS	Median	All	0.425	0.732	<.001	93	view →
UVM	OS	Tertile	All	0.387	0.929	<.001	81	view →
KIRP	OS	Median	All	0.536	0.930	<.001	73	view →
READ	DFS	Median	III,IV	0.864	0.616	.001	61	view →
SARC	OS	Tertile	All	0.627	0.847	<.001	39	view →
LGG	OS	Median	All	0.859	0.931	<.001	29	view →
MESO	OS	Median	III,IV	0.283	0.728	.005	26	view →
CESC	DFS	Quartile	IV	0.068	0.564	.021	24	view →
KICH	OS	Quartile	All	0.548	1.000	.007	22	view →
BRCA	OS	Median	II,III,IV	0.515	0.629	.001	21	view →
ACC	OS	Median	II,III,IV	0.686	0.952	.009	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

PIGU–LIHC (OS)

Open the LIHC breakdown →