PIGU

Across TCGA patient cohorts, PIGU mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIGU-associated genes across cancer lineages are 14-3-3_beta, eIF4E, and Fibronectin. Each is linked with PIGU in more than 1 cancer types. Because this analysis shows association rather than direction, both PIGU-to-partner and partner-to-PIGU results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by PIGU-low versus PIGU-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGU→partner) and Y-score (partner→PIGU) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.085	-2.973	.046	.035	3	1
UCEC	eIF4E →	+0.198	+2.906	.026	.001	3	1
UCEC	Fibronectin →	-0.385	-4.000	.005	<.001	3	1
UCEC	ACC_pS79 →	+0.353	+2.321	.016	.033	3	1
UCEC	HER2_pY1248 →	-0.228	-2.459	.044	.019	3	1
UCEC	Src_pY416 →	-0.212	-1.687	.038	.044	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

14-3-3_beta by PIGU expression — UCEC

Explore this box plot interactively →