PIGR

Across TCGA patient cohorts, PIGR mutation is significantly associated with the RNA expression of many other genes, with 2,142 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIGR-associated genes across cancer lineages are OR8B8, CYCSP19, and LINC01072. Each is linked with PIGR in more than 2 cancer types. Because this analysis shows association rather than direction, both PIGR-to-partner and partner-to-PIGR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8B8 grouped by PIGR-low versus PIGR-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGR→partner) and Y-score (partner→PIGR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	OR8B8 →	+0.009	+3.293	<.001	<.001	3	3
HNSC	CYCSP19 →	+0.283	+3.838	<.001	.005	3	2
CESC	LINC01072 →	+0.203	+5.345	<.001	.001	3	2
CESC	VTRNA2-2P →	+0.432	+4.601	<.001	.004	3	2
CESC	MIR4510 →	+0.300	+5.342	<.001	.002	3	2
SKCM	KCNH1-IT1 →	+0.604	+1.735	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,142 associations by consensus.

OR8B8 by PIGR expression — SKCM

Explore this box plot interactively →