PIGR

Across TCGA pan-cancer cohorts, PIGR RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PIGR data layer compared with 5 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where higher PIGR RNA is associated with better overall survival. In most high-consensus cancer types, elevated PIGR expression acts as an unfavorable survival marker, although some lineages such as KIRP and BRCA show a favorable association.

KIRP, BRCA, and MESO are the cancer types where PIGR RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRP	OS	Tertile	All	0.814	0.630	<.001	134	view →
BRCA	OS	Tertile	All	0.974	0.941	<.001	80	view →
MESO	DFS	Tertile	All	0.499	0.223	<.001	60	view →
READ	DFS	Median	All	0.720	0.405	.001	22	view →
ESCA	OS	Quartile	All	0.375	1.000	.009	19	view →
COAD	DFS	Quartile	All	0.811	0.582	.002	17	view →
THCA	OS	Median	III,IV	0.988	0.901	.008	14	view →
UCEC	DFS	Median	All	0.711	0.585	<.001	12	view →
HNSC	OS	Median	All	0.310	0.502	.012	11	view →
LGG	OS	Tertile	All	0.729	0.892	.013	9	view →
LUAD	DFS	Quartile	All	0.848	0.754	.019	9	view →
UVM	DFS	Tertile	II,III,IV	0.324	0.693	.041	8	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PIGR–KIRP (OS)

Open the KIRP breakdown →