PIGO

Across TCGA cell cohorts, PIGO mutation is significantly associated with the RNA expression of many other genes, with 853 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIGO-associated genes across cancer lineages are SAMM50, MAPK8, and BMPR1A. Each is linked with PIGO in more than 1 cancer types. Because this analysis shows association rather than direction, both PIGO-to-partner and partner-to-PIGO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SAMM50 grouped by PIGO-low versus PIGO-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGO→partner) and Y-score (partner→PIGO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SAMM50 →	+0.507	+3.252	.001	.002	3	2
LARGE_INTESTINE	MAPK8 →	+0.595	+3.169	.004	.009	3	2
LARGE_INTESTINE	BMPR1A →	+0.734	+2.936	<.001	<.001	3	2
LARGE_INTESTINE	NEIL3 →	+0.710	+2.652	<.001	.001	3	2
LARGE_INTESTINE	TTC19 →	+0.729	+3.459	<.001	.001	3	2
LARGE_INTESTINE	THUMPD3 →	+0.468	+2.590	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 853 associations by consensus.

SAMM50 by PIGO expression — LARGE_INTESTINE

Explore this box plot interactively →