PIGO

Across TCGA pan-cancer cohorts, PIGO RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated PIGO data layer compared with 10 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PIGO RNA is associated with better overall survival. In most high-consensus cancer types, elevated PIGO expression acts as an unfavorable survival marker, although some lineages such as KIRC and UCS show a favorable association.

KIRC, UVM, and MESO are the cancer types where PIGO RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.771	0.513	<.001	81	view →
UVM	DFS	Median	III,IV	0.439	0.914	.003	61	view →
MESO	DFS	Tertile	II,III,IV	0.167	0.652	.006	39	view →
UCS	DFS	Median	IV	0.952	0.367	.001	36	view →
LIHC	OS	Median	All	0.600	0.767	<.001	31	view →
ACC	DFS	Quartile	All	0.205	0.752	<.001	28	view →
SCLC	OS	Tertile	All	0.668	0.360	.002	27	view →
LUAD	DFS	Median	IV	0.666	0.978	.015	26	view →
CESC	DFS	Quartile	III,IV	0.567	0.938	.005	14	view →
BRCA	OS	Quartile	III,IV	0.924	0.749	.008	14	view →
OV	DFS	Quartile	IV	0.637	0.334	.009	10	view →
SKCM	DFS	Median	All	0.684	0.821	.004	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

PIGO–KIRC (OS)

Open the KIRC breakdown →