PIGL

Across TCGA patient cohorts, PIGL mutation is significantly associated with the RNA expression of many other genes, with 156 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIGL-associated genes across cancer lineages are KLF17P2, RNU6-1089P, and RN7SL612P. Each is linked with PIGL in more than 1 cancer types. Because this analysis shows association rather than direction, both PIGL-to-partner and partner-to-PIGL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KLF17P2 grouped by PIGL-low versus PIGL-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGL→partner) and Y-score (partner→PIGL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	KLF17P2 →	+0.192	+4.595	<.001	.004	3	1
SKCM	RNU6-1089P →	+0.442	+6.356	<.001	<.001	3	1
SKCM	RN7SL612P →	+0.147	+4.268	.008	.008	3	1
SKCM	RN7SL712P →	+0.167	+6.219	<.001	<.001	3	1
BRCA	MIR1237 →	+0.397	+7.731	<.001	.009	3	1
BRCA	RN7SKP221 →	+0.099	+8.471	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 156 associations by consensus.

KLF17P2 by PIGL expression — SKCM

Explore this box plot interactively →