PIGL

Across TCGA pan-cancer cohorts, PIGL RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated PIGL data layer compared with 4 for mutation status.

The strongest signal is observed in uveal melanoma (UVM), where higher PIGL RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated PIGL expression acts as an unfavorable survival marker, although some lineages such as BRCA and SKCM show a favorable association.

UVM, KIRC, and BRCA are the cancer types where PIGL RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Quartile	II,III,IV	0.318	0.891	<.001	85	view →
KIRC	DFS	Tertile	II,III,IV	0.357	0.628	<.001	79	view →
BRCA	OS	Tertile	All	0.984	0.938	<.001	66	view →
KICH	OS	Tertile	All	0.676	1.000	.011	48	view →
LGG	DFS	Median	All	0.668	0.805	<.001	47	view →
SKCM	OS	Tertile	All	0.435	0.290	<.001	36	view →
PRAD	DFS	Median	All	0.715	0.819	<.001	34	view →
KIRP	OS	Median	III,IV	0.149	0.738	.006	24	view →
ACC	DFS	Tertile	IV	0.063	0.590	.001	22	view →
LAML	DFS	Median	All	0.516	0.283	.014	20	view →
BLCA	OS	Median	II,III,IV	0.781	0.653	.004	15	view →
READ	OS	Median	II,III,IV	0.774	0.485	.032	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

PIGL–UVM (DFS)

Open the UVM breakdown →