PIGL

Across TCGA pan-cancer cohorts, PIGL RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PIGL’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PIGL RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PIGL is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

HNSC, COAD, and KICH are the cancer types where PIGL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PIGL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.600	<.001	12	view →
COAD	Male	III,IV	+0.796	<.001	10	view →
KICH	Female	All	−0.752	<.001	7	view →
STAD	Male	II,III,IV	+0.659	.001	7	view →
LIHC	Female	II,III,IV	+0.496	<.001	7	view →
BLCA	All	III,IV	+0.427	.002	7	view →
BRCA	All	III,IV	−0.600	<.001	6	view →
CHOL	All	All	+1.024	<.001	3	view →
KIRC	All	All	+0.187	.001	3	view →
READ	Female	All	+0.758	<.001	2	view →
KIRP	All	II,III,IV	+0.375	.042	2	view →
UCEC	All	All	−0.302	.037	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PIGL–HNSC

Open the HNSC breakdown →