PIGL

Across TCGA cell cohorts, PIGL RNA expression is significantly associated with the go_rna of many other GO terms, with 3,037 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PIGL-associated GO terms across cancer lineages are Negative regulation of telomere maintenance, Regulation of telomere maintenance via telomerase, and DNA topological change. Each is linked with PIGL in more than 9 cancer types. Because this analysis shows association rather than direction, both PIGL-to-partner and partner-to-PIGL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of telomere maintenance grouped by PIGL-low versus PIGL-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGL→partner) and Y-score (partner→PIGL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Negative regulation of telomere maintenance →	+0.079	+1.082	<.001	<.001	3	10
LUNG_SCLC	Regulation of telomere maintenance via telomerase →	+0.065	+0.647	<.001	<.001	3	10
LUNG_SCLC	DNA topological change →	+0.116	+0.759	<.001	<.001	3	10
BREAST	Regulation of translation at synapse, modulating synaptic transmission →	+0.106	+0.906	<.001	<.001	3	9
STOMACH	Negative regulation of brown fat cell differentiation →	+0.224	+1.011	.001	.005	3	9
LARGE_INTESTINE	'de novo' IMP biosynthetic process →	+0.102	+0.793	.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,037 associations by consensus.

Negative regulation of telomere maintenance by PIGL expression — URINARY_TRACT

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