PIGB

Across TCGA patient cohorts, PIGB mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIGB-associated genes across cancer lineages are PCNA, A-Raf_pS299, and ERK2. Each is linked with PIGB in more than 1 cancer types. Because this analysis shows association rather than direction, both PIGB-to-partner and partner-to-PIGB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by PIGB-low versus PIGB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGB→partner) and Y-score (partner→PIGB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.194	+1.807	.010	.025	3	2
UCEC	A-Raf_pS299 →	-0.113	-3.584	.007	.002	3	1
UCEC	ERK2 →	+0.174	+2.459	.010	.018	3	1
UCEC	INPP4B →	-0.283	-2.459	.013	.018	3	1
UCEC	JNK_pT183_Y185 →	-0.123	-1.349	.039	.037	3	1
UCEC	JNK2 →	+0.210	+2.486	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

PCNA by PIGB expression — UCEC

Explore this box plot interactively →