PIGB

Across TCGA cell cohorts, PIGB RNA expression is significantly associated with the go_rna of many other GO terms, with 3,220 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible PIGB-associated GO terms across cancer lineages are Cytoplasmic pattern recognition receptor signaling pathway, Xenophagy, and Negative regulation of transcription initiation-coupled chromatin remodeling. Each is linked with PIGB in more than 9 cancer types. Because this analysis shows association rather than direction, both PIGB-to-partner and partner-to-PIGB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cytoplasmic pattern recognition receptor signaling pathway grouped by PIGB-low versus PIGB-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGB→partner) and Y-score (partner→PIGB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Cytoplasmic pattern recognition receptor signaling pathway →	+0.088	+0.810	.002	.003	2	10
LIVER	Xenophagy →	+0.181	+0.805	<.001	<.001	3	9
CNS	Negative regulation of transcription initiation-coupled chromatin remodeling →	-0.094	-0.454	.003	.002	3	8
SOFT_TISSUE	Intracellular pH reduction →	+0.058	+0.748	.002	<.001	3	7
SOFT_TISSUE	Regulation of intracellular pH →	+0.066	+0.893	<.001	<.001	3	7
LARGE_INTESTINE	Regulation of pH →	+0.060	+0.500	<.001	.005	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,220 associations by consensus.

Cytoplasmic pattern recognition receptor signaling pathway by PIGB expression — LUNG_NSCLC_LUSC

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