PIGB

Across TCGA cell cohorts, PIGB mutation is significantly associated with the RNA expression of many other genes, with 40 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PIGB-associated genes across cancer lineages are CT47B1, KRTAP4-2, and PRSS54. Each is linked with PIGB in more than 1 cancer types. Because this analysis shows association rather than direction, both PIGB-to-partner and partner-to-PIGB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CT47B1 grouped by PIGB-low versus PIGB-high in BREAST.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIGB→partner) and Y-score (partner→PIGB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CT47B1 →	+0.015	+4.421	.002	.004	3	1
BREAST	KRTAP4-2 →	+0.025	+4.781	<.001	.003	3	1
CNS	PRSS54 →	+0.057	+4.754	<.001	.005	3	1
CNS	PRAMEF33 →	+0.387	+4.321	<.001	.009	3	1
LARGE_INTESTINE	TBX18 →	+1.100	+3.537	<.001	.001	3	1
LARGE_INTESTINE	CSPG5 →	+0.742	+3.169	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

CT47B1 by PIGB expression — BREAST

Explore this box plot interactively →