PIAS4

Across TCGA patient cohorts, PIAS4 mutation is significantly associated with the RNA expression of many other genes, with 1,993 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PIAS4-associated genes across cancer lineages are ZNF736P7Y, RNA5SP411, and RNU6-13P. Each is linked with PIAS4 in more than 1 cancer types. Because this analysis shows association rather than direction, both PIAS4-to-partner and partner-to-PIAS4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZNF736P7Y grouped by PIAS4-low versus PIAS4-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PIAS4→partner) and Y-score (partner→PIAS4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	ZNF736P7Y →	+0.059	+5.320	.001	.001	3	2
UCEC	RNA5SP411 →	+1.313	+2.393	<.001	<.001	3	2
COAD	RNU6-13P →	+0.704	+4.893	<.001	<.001	3	2
COAD	RNA5SP33 →	+1.159	+3.285	<.001	.003	3	2
COAD	RNU6-866P →	+0.573	+2.800	<.001	.008	3	2
UCEC	RNA5SP419 →	+0.918	+2.787	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,993 associations by consensus.

ZNF736P7Y by PIAS4 expression — BLCA

Explore this box plot interactively →