PIAS4

Across TCGA pan-cancer cohorts, PIAS4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of PIAS4’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PIAS4 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PIAS4 is over-expressed in tumor.

HNSC, KIRC, and BLCA are the cancer types where PIAS4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PIAS4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.026	<.001	11	view →
KIRC	Female	All	+0.489	<.001	11	view →
BLCA	All	All	+0.532	<.001	9	view →
LIHC	Female	III,IV	+1.174	<.001	8	view →
LUSC	All	II,III,IV	+0.774	<.001	7	view →
COAD	Female	II,III,IV	+0.490	<.001	7	view →
BRCA	All	II,III,IV	+0.488	<.001	6	view →
STAD	Male	II,III,IV	+0.739	.001	5	view →
KIRP	All	II,III,IV	+0.313	.024	4	view →
CHOL	Female	All	+2.020	<.001	3	view →
ESCA	All	All	+0.793	.005	2	view →
PRAD	All	All	+0.233	.006	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

PIAS4–HNSC

Open the HNSC breakdown →